Tag: pyrrolobenzodiazepines
What is Pyrrolobenzodiazepine (PBD)?
Pyrrolobenzodiazepine (PBD)
Chemical Name: Diazepinoindole;
Molecular Formula: C14H14N2O3
Molecular weight: 258,27 g/mole
Average mass: 181.193 Da
Monoisotopic mass: 181.063995 Da
Introduction
Discovered in 1963, the pyrrolobenzodiazepines (PBDs) are a class of antitumor antibiotics...
ADCs – The Dawn of a New Era?
Two decades ago, ADCs were hailed as a major breakthrough, especially in the area of oncology therapeutics. The concept of delivering a potent drug payload directly to the site of the tumor for maximum effect with minimal damage caused to non-cancerous cells was viewed as, if not the Holy Grail of cancer treatment, at least a significant advance towards precision medicine. However, the concept has proved difficult to translate into clinical success.
