Home Must Read Articles

Must Read Articles

Immunocapture-liquid Chromatography/Mass Spectrometry in Simultaneous Quantification of Total Antibody and ADC for XMT-1522 in...

XMT-1522, an investigational antibody-drug conjugate (ADC) being developed by Mersana Therapeutics and Takeda, represents the first Dolaflexin®-based, cleavable ADC...
One red Dutch tulip

Trastuzumab Duocarmazine for Treatment of HER2-Expressing Breast Cancer

Trastuzumab duocarmazine* (SYD985; Synthon) is a novel antibody-drug conjugate composed of the recombinant humanized anti-epidermal growth factor receptor 2...

A Review of Cleavable Linkers

With 5 commercially available antibody-drug conjugates (ADCs) an nearly 100 novel agents in developments - from early discovery to...
Magazines heap detail

New Reagents for the Rapid Generation of Efficacious Antibody-drug Conjugates

Because conjugation selectivity as well as stability and hydrophobicity of linkers and payloads drastically influence the performance and safety...

Anti-CD205 Antibody-Drug Conjugate MEN1309/OBT076 Shows Substantial in vitro Antitumor Activity

Non-clinical study findings published in the journal Molecular Cancer Therapeutics describing the characterization of the anti-CD205 antibody-drug conjugate (ADC)...
Featured Image: General views at the American Society for Clinical Oncology (ASCO) annual meeting. Courtesy: © ASCO/Max Gersh 2015. Used with permission.

New Data Demonstrates Potential for RemeGen’s RC48 in HER2+ Cancers

Results from a robust oncology pipeline, including the latest phase II data of an investigational antibody-drug conjugates (ADC) called...
The sign I Amsterdam in front of rijksmuseum in Amsterdam, The Netherlands.

Sutro Presents Preliminary Results From Ongoing Phase I Study of STRO-001

California-based Sutro Biopharma has confirmed that the company will present preliminary results from the first 14 patients enrolled in...
Magazines heap detail

Site Specific Conjugation of Hydrophobic Payloads Without Genetic Engineering

Site-specific conjugation leads to more homogeneous conjugates and allows control of the site of drug attachment. This approach frequently...
Featured Image: Journal + glasses. Courtesy: © 2017 - 2019. Fotolia. Used with permission.

Understanding of the Underlying Mechanisms of Target-Independent Uptake and Toxicity

With 4 approved agents, antibody-drug conjugates or ADC have shown to be a very promising class of therapeutics.While the...

First-in-class Immunotherapeutic Approach Shows Efficacy in Neuroblastoma

Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia (CHOP) have developed a preclinical, potent therapy attached to...

FEATURED RESOURCES