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Featured Image: American Society of Hematology | Annual Meeting. Courtesy: © 2017. American Society of Hematology. Used with permission.

What to Expect at ASH 2019: Seattle Genetics

With the 61st annual meeting of the American Society of Hematology about to begin, here are some of the...
Featured Image: London Tower Bridge. Photo Courtesy: 2018 Fotolia

Zymeworks, Regeneron, Boehringer Ingelheim Pharma and Many Others are Betting on Antibody-Drug-Conjugates

Antibody-Drug -Conjugates (ADCs) have the potential to reduce off-target toxicities in patients by limiting the exposure of normal tissues...

What’s New in ADCs: 10th Annual World ADC Wrap-up

Hello ADC World:We have something a little different in store for today.  Today is a feature on the 10th...
General Views during at the American College of Rheumatology Annual Meeting, held November 8 - 13, 2019 in Atlanta, Georgia. Photo courtesy 2019 © ACR.

First Immune Reset with Single dose of CD45-ADC in Multiple Autoimmune Diseases

Data showing successful immune reset with a single dose of CD45-ADC, an antibody-drug conjugate, in models of three autoimmune...
Bayer researchers in one of Bayer’s cell culture laboratories in Berlin, Germany. Courtesy: Bayer

Antibody-drug Conjugates with Novel Kinesin Spindle Protein Inhibitor Payloads and a Tailor-made Linker Chemistry

With the approval of meanwhile five ADCs and more than 80 ADCs in clinical trials, the ADC landscape has...
Featured Image: Ado-trastuzumab emtansine (Kadcyla; Genentech/Roche), known as T-DM1 during. Courtesy: Genentech/Roche.

Pharmacokinetic Considerations to Maximize an ADC’s Therapeutic Index

The Antibody-drug Conjugate (ADC) field is poised for several significant advances in solid tumors as the industry has built...
Photo: San Deigo Bay from Harbor Drive, San Diego, CA, USA. Photo Courtesy: This photo has been released into the public domain by its author, Jon Sullivan. This applies worldwide.

From First-in-Human to Post-Commercial: ADC Reference Materials and Specifications

The 2019 World ADC conference in San Diego, CA, held October 8 – 11, 2019, started with a day...
Featured Image: Boston Public Garden; Boston, MA. Courtesy: © 2017 Fotolia. Used with permission.

Encouraging Preliminary Clinical Data in Ongoing Phase I Study for STRO-002 in Patients with...

Initial safety data of STRO-002 shows potent anti-tumor activity in preclinical endometrial cancer patient-derived xenograft (PDX) models were presented...
Gesso Italiano (Italian Chalk) in San Diego's Little Italy neighborhood celebrating its heritage by bringing the vibrancy and flavors of Italy to southern California. Courtesy: 2016 Fotolia.

Advanced Design of ADCs: Principles and Applications using Next Generation Linkers and Site-Specific Technology

Over the years there have been major challenges in the development of antibody-drug conjugates (ADC), including: choosing the right...
Featured Image - Laboratory. Courtesy 2019 Fotolia

Study Demonstrates Superior Efficacy and Cytotoxicity of Femtogenix’s Sequence-selective DNA-interactive Payload

Data verifying a favorable toxicity profile and potent efficacy of a novel pyrridinobenzodiazepine (PDD) antibody-drug conjugate payload platform in...