Boston-based Conagen, a synthetic biology company and a leader in bioengineering, has acquired a fermentation-based technology for the production of therapeutically useful glycoproteins. The acquisition includes several patents covering the platform and all associated tangible assets. This establishes Conagen as a leading developer of active pharmaceutical ingredients (APIs).

In addition to a suite of more than 10 already developed therapeutic glycoproteins, Conagen, which traditionally focuses on the bioproduction of high-value ingredients for food, nutrition, flavor and fragrance, pharmaceutical, and renewable materials industries, will us the host platform for development of both novel and generic drugs.

Industrial fermentation
Industrial fermentation typically employs microbes which can be cultured rapidly at the largest scales without cell disruption or losses in productivity. Characteristics of these therapeutics, which include desirable glycostructures and other post-translational modifications, have limited their commercial production to fragile mammalian cell systems at relatively small scales.

“One of the most exciting features of this host organism is its ability to express glycoproteins harboring glycostructures which promote the desired immune cell functions. This is a very unusual feature to find in a robustly fermentable microbe. It is also advantaged by its ability to tolerate the engineering required to customize these glycostructures while preserving the microbe’s robustness,” said Vice President of Research and Development, Casey Lippmeier

Advertisement #3 
Lonza 2024

Reducing costs of medication
The platform will reduce costs, and the savings can be passed down to patients. This is important to the pharmaceutical industry which is under increasing pressure to reduce time and capital in developing drugs,” said Oliver Yu, Ph.D., co-founder, and Chief Executive Officer of Conagen.

The largest category of therapeutic glycoproteins is the blockbuster monoclonal antibodies upon which the entire U.S. $ 100 billion immunotherapy and antibody-drug conjugate (ADC) market is based.

Advertisement #4