IgG1 monoclonal antibody (immunoglobulin)
IgG1 monoclonal antibody (immunoglobulin). Many biotech drugs are antibodies. Atoms are shown as color-coded spheres. Light chain shaded blue, heavy chain cyan.

Authors: Zarei O, Benvenuti S, Ustun-Alkan F, Hamzeh-Mivehroud M, Dastmalchi S.
Title: Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer therapy and drug delivery.
Published in: J Cancer Res Clin Oncol. 2016 Dec;142(12):2429-2446. Epub 2016 Aug 8.

Keywords: Cancer; Drug conjugate; Monoclonal antibody; Peptide; Target therapy; Tumor; Tyrosine kinase receptor

Cancer is one of the most important life-threatening diseases in the world. The current efforts to combat cancer are being focused on molecular-targeted therapies. The main purpose of such approaches is based on targeting cancer cell-specific molecules to minimize toxicity for the normal cells. RON (Recepteur d’Origine Nantais) tyrosine kinase receptor is one of the promising targets in cancer-targeted therapy and drug delivery.

ADC Bio
Lonza
MabPlex
 

In this review, we will summarize the available agents against extracellular domain of RON with potential antitumor activities.

The presented antibodies and antibody drug conjugates against RON in this review showed wide spectrum of in vitro and in vivo antitumor activities promising the hope for them entering the clinical trials.

Due to critical role of extracellular domain of RON in receptor activation, the development of therapeutic agents against this region could lead to fruitful outcome in cancer therapy.


Author affiliation:

  • Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Molecular Therapeutics and Exploratory Research Laboratory, Candiolo Cancer Institute-FPO-IRCCS, Candiolo, Turin, Italy.
  • Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Istanbul University, Istanbul, Turkey.
  • Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. [email protected]
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. [email protected]
  • Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. [email protected]
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. [email protected]

Featured Image: IgG1 monoclonal antibody (immunoglobulin). Courtesy: © Fotolia. Used with Permission.


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