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First-Patient Dosed with BRY812 in Phase I Trial

A first patient has been dosed in a Phase I Clinical trial of BRY812, a third-generation antibody-drug conjugate (ADC) targeting LIV-1 being developed by BioRay Pharmaceutical Co., for the treatment of advanced malignant tumors.

Pyxis Oncology to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary...

The US Food and Drug Administration (FDA) has cleared two Investigational New Drug (IND) applications from Cambridge, Massachusetts-based biotech Pyxis Oncology, allowing the company to...

Corbus Expands Oncology Pipeline with Clinical Stage Nectin-4 Targeting ADC

Corbus Pharmaceuticals, a precision oncology company, today announced that it has entered into an exclusive licensing agreement with CSPC Megalith Biopharmaceutical, a subsidiary of...

Adcendo Licenses Duality Biologics’ DITAC Linker-Payload Technology Platform for its Lead...

Denmark's Adcendo, a biotech company focused on the development of breakthrough antibody-drug conjugates (ADCs) for the treatment of underserved cancers, has signed a licensing agreement with Duality Biologics, a clinical-stage biotech company focused on discovering and developing a pipeline of ADCs targeting cancers and autoimmune diseases.

Eric Rosenthal Reports: Why Academia Wasn’t Ready to Build Big Data...

Big news hit the pharmaceutical industry in February when Roche Pharmaceuticals announced that it would be acquiring big-data firm Flatiron Health for $1.9 billion. Roche...

Novel Approach may Limit the Troubling Side Effects of Cancer Immunotherapy

Connecting highly effective cancer immunotherapy drugs such as anti-CTLA4 (ipilimumab | Yervoy®; Bristol-Myers Squibb Company) and anti-PD-L1 (atezolizumab | Tecentriq®; Genentech) to peptides that...

Study looks at Efficacy and Metabolism of Azonafide-based ADCs in Microgravity

A new study is investigating the efficacy and metabolism of azonafide-based antibody-drug conjugates (ADCs) in microgravity. The investigators seeks to activate immunogenic cell death...
Laser therapy of cancer concept

What Governments Can Do To Address Cancer

While much work remains to find a cure for cancer – the good news is we know that many forms of cancer are preventable....

To Reimburse or not to Reimburse – That is the Question

Novel, innovative (bio)pharmaceutical drugs are an important part of our global healthcare system, offering advanced, radical new personalized and targeted therapy options to patients...

Antibody-drug conjugates: Recent Advances in Conjugation and Linker Chemistries

Authors: Tsuchikama K , An Z Title: Antibody-drug conjugates: recent advances in conjugation and linker chemistries. Published in: Protein Cell. 2016 Oct 14. Keywords: antibody-drug conjugates; cancer;...

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