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Eric Rosenthal Reports: Why Academia Wasn’t Ready to Build Big Data...

Big news hit the pharmaceutical industry in February when Roche Pharmaceuticals announced that it would be acquiring big-data firm Flatiron Health for $1.9 billion. Roche...

Novel Approach may Limit the Troubling Side Effects of Cancer Immunotherapy

Connecting highly effective cancer immunotherapy drugs such as anti-CTLA4 (ipilimumab | Yervoy®; Bristol-Myers Squibb Company) and anti-PD-L1 (atezolizumab | Tecentriq®; Genentech) to peptides that...

Study looks at Efficacy and Metabolism of Azonafide-based ADCs in Microgravity

A new study is investigating the efficacy and metabolism of azonafide-based antibody-drug conjugates (ADCs) in microgravity. The investigators seeks to activate immunogenic cell death...
Laser therapy of cancer concept

What Governments Can Do To Address Cancer

While much work remains to find a cure for cancer – the good news is we know that many forms of cancer are preventable....

To Reimburse or not to Reimburse – That is the Question

Novel, innovative (bio)pharmaceutical drugs are an important part of our global healthcare system, offering advanced, radical new personalized and targeted therapy options to patients...

Antibody-drug conjugates: Recent Advances in Conjugation and Linker Chemistries

Authors: Tsuchikama K , An Z Title: Antibody-drug conjugates: recent advances in conjugation and linker chemistries. Published in: Protein Cell. 2016 Oct 14. Keywords: antibody-drug conjugates; cancer;...

Outsmarting Cancer – From the War on Cancer to the Cancer...

On May 25, 1961, President John F. Kennedy announced, before a special joint session of congress, the dramatic and ambitious goal of sending a...

Enhancing Activity of Sacituzumab Govitecan in SN-38-Resistant Cancer

Adding an inhibitor of ATP-binding cassette (ABC) transporters to sacituzumab govitecan increased the median survival of mice bearing a SN-38-resistant human gastric cancer cell...
IgG1 monoclonal antibody (immunoglobulin)

Strategies of Targeting the Extracellular Domain of RON Tyrosine Kinase Receptor...

Authors: Zarei O, Benvenuti S, Ustun-Alkan F, Hamzeh-Mivehroud M, Dastmalchi S. Title: Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer...

Avacta and Glythera Partner to Develop Novel, Highly Targeted, Drugs

Avacta Life Sciences, the developer of Affimer® biotherapeutics and research reagents will collaborate with Glythera a developer of advanced, stable conjugation chemistries and novel, ultra-potent...