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Novel Payloads for Antibody-drug Conjugates

The development of antibody-drug conjugates or ADCs, has resulted in the need of developing novel compounds that can be used as payloads. Enediynes, represented by...

ADC Biotechnology Secures Funding for Strategic move into Downstream Formulation and...

UK-based ADC Biotechnology, an innovative biotechnology company developing new process technology to speed, simplify and significantly lower the production costs of antibody-drug conjugates, has...

Four Ways to Show Nonobviousness of ADC Inventions

As research continues to progress and the scientific community’s appreciation for the power of ADCs has grown, so have the numbers. FDA has now approved at least four ADCs, and hundreds more are in development. The number of patent applications has also grown, with the U.S. Patent and Trademark Office (USPTO) publishing over two hundred patent applications with claims to ADC inventions in the last two years alone.

Are Small-Format Drug Conjugates a Viable ADC Alternative Solid Tumors?

Antibody-drug conjugates or ADCs are complex immunoconjugates. They are designed to selectively deliver a small-molecules cytotoxic payload to cancer cells. Directed to specific tumor...

Gemtuzumab Ozogamicin Granted Positive Opinion for Treatment of Previously Untreated, De...

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted positive opinions recommending that two Pfizer hematology...

Lifastuzumab Vedotin is Well-tolerated + Improves Objective Response Rate in Phase...

Lifastuzumab vedotin, also known as DNIB0600A (RO5541081) and RG-7599, is an antibody-drug conjugate or ADC. In clinical trials the investigational drug is compared to pegylated...

University of Copenhagen’s Spin-out company ADCendo to Explore and Commercialize Novel...

Earlier this year spin-out company ADCendo, the University of Copenhagen and the Capital Region of Denmark entered into a worldwide license agreement to develop...

Annual World ADC Awards 2017: And the Winner is…

Earlier this month, the 8th World ADC meeting, held September 20 - 22, 2017 in San Diego and organized by Hanson Wade, offered a...

Registration of Antibody Drug Conjugates

Abstract      Antibody Drug Conjugates (ADC) are a rapidly expanding area of pharma company pipelines. They combine the targeting of an antibody with the potency...

Antibody-drug Conjugates: Intracellular Trafficking of New Anticancer Therapeutics

A new article, published by a team of writers including Muhammad Kalim, Jie Chen, and Shenghao Wang from the Department of Biochemistry and Genetics,...