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TRPH-222, a Novel Anti-CD22 ADC, has Significant Anti-Tumor Activity in NHL

A preclinical abstract describing TRPH-222, also known as CAT-02-106, an anti-CD22 antibody-drug conjugate or ADC being developed by Triphase Accelerator for the treatment of...

Antibody-drug Conjugate Targeting CD46 Eliminates Multiple Myeloma Cells

Authors: Sherbenou DW , Aftab BT , Su Y, Behrens CR , Wiita A, Logan AC , Acosta-Alvear D, Hann BC , Walter...
European Hematology Association

Preclinical Data of Novel Antibody-drug Conjugate IMGN779 Demonstrates Potent Activity Against...

Results from a preclinical trial shows that IMGN779, a novel, DNA-alkylating, anticancer therapeutics based on ImmunoGen, Inc, antibody-drug conjugates (ADC) technology, shows potent activity against CD33-expressing acute myeloid leukemia cells,including leukemic stem cells, while sparing normal cells.

Clinical Trial with Inotuzumab Ozogamicin in Relapsed or Refractory Aggressive Non-Hodgkin...

Earlier today, Pfizer Inc. confirmed that it had discontinued a Phase III randomized, open-label, two-arm study (B1931008) evaluating the safety and efficacy of the...

New CD33-Directed Antibody-Drug Conjugate, Utilizing Pyrrolobenzodiazepine Dimers, Demonstrates Anti-tumor Activity in...

Preclinical data from SGN-CD33A (Seattle Genetics, Inc), a novel CD33-directed antibody-drug conjugate (ADC) in development for the treatment of acute myeloid leukemia (AML) presented at...

Novel Drugs Breaks Down Barriers – Attacks Breast Cancer Cells from...

Throwing stones at castle walls is one way to attack an enemy, but sneaking inside makes the target much more vulnerable. Researchers at Cedars-Sinai's...

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