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Axplora Advances European Exatecan Supply Route for Topoisomerase I Inhibitor ADCs

Axplora announced the completion of its first research and development batches of exatecan, a camptothecin-class topoisomerase I inhibitor, to establish an additional European source for antibody-drug conjugate (ADC) developers [1]. The company said exatecan development and manufacture are based at its Farmabios site in Gropello Cairoli, Italy, and linked to payload-linker development and bioconjugation operations at its Novasep CDMO site in Le Mans, France [1]. Validation batches are targeted before the end of 2026, with initial GMP supply targeted for late 2027 [1].

Validation of ADC Platform for Protein Concentration and the Drug-Antibody Ratio...

Antibody Drug Conjugates (ADCs) are biopharmaceutical drugs which are designed to treat cancer by targeting and killing the cancerous cells while leaving the healthy...

Lonza Expands its Bioconjugation Facility with Two Additional Manufacturing Suites and...

Lonza is expanding its bioconjugation capabilities at its Visp in Switzerland. The expansion adds two production suites to the existing conjugation facility providing development...

Lonza to Provide Customer-Dedicated Suites for Commercialization of Bioconjugates

Lonza, in a statement, confirmed signing a strategic collaboration for bioconjugation with a global biopharma company. Under the terms of the agreement, Lonza will construct...
WuXi Biologics Conjugation Solution Center

WuXi Biologics Expands Integrated Biologics Conjugation Solution Center

WuXi Biologics ("WuXi Bio") (2269.HK), a leading global open-access biologics technology platform company offering end-to-end solutions for biologics discovery, development and manufacturing, announced that...

Downstream Bioconjugation Model May Reduce Overall ADC Development Cost

A 'downstream bioconjugation' method may present a new model in antibody-drug conjugate development and manufacturing. In contrast to the existing approaches – which undertake...

ADC Biotechnology Invests in New Bioconjugation Facility in North Wales, United...

UK-based ADC Biotechnology has secured investment for the construction of an $11 million* bioconjugation facility at its new site in Deeside, North Wales, UK. The...

Novasep finalizes €11M bioconjugation facility in Le Mans, France

Thius week, following the World ADC Summit in Berlin, Germany, Novasep, a leading supplier of services and technologies for the life sciences industry, announced...

Novasep Expands It’s North American Facility: Adding A Synthesis Laboratory...

Lyon (France) -based Novasep, a leading supplier of services and technologies for the life sciences industry is building a new synthesis laboratory and a...

Althea Expands Simplified Manufacturing Supply Chain Service for ADC Development

Biopharmaceutical contract development and manufacturing organization (CDMO) Ajinomoto Althea earlier today announced that it is expanding its existing biological drug product manufacturing operations to include highly...