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Conditionally Active Biologics (CAB)

Novel pH Mechanism may Enhance On-Target Effects with Reduced Off-Tumor Toxicity

The development of antibody-based immunotherapies has, compared with conventional therapeutic strategies patients, transformed the therapeutic landscape in melanoma, non-small cell lung cancer, bladder cancer,...

FDA Accepts Investigational New Drug Application for CTLA-4 Probody Therapeutic

Bristol-Myers Squibb has received acceptance of the Investigational New Drug application (IND) from the U.S. Food and Drug Administration (FDA) for a CTLA-4-directed Probody™...