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Study Links Gemtuzumab Ozogamicin Response in Pediatric AML to Expression Level...

Expression CD33 is largely restricted to hematopoietic cells. Because CD33 is consistently expressed on acute myeloid leukemia or AML blasts, it makes a promising...
European Hematology Association

Preclinical Data of Novel Antibody-drug Conjugate IMGN779 Demonstrates Potent Activity Against...

Results from a preclinical trial shows that IMGN779, a novel, DNA-alkylating, anticancer therapeutics based on ImmunoGen, Inc, antibody-drug conjugates (ADC) technology, shows potent activity against CD33-expressing acute myeloid leukemia cells,including leukemic stem cells, while sparing normal cells.

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