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Sanofi Collaborates with Innate Pharma on Next Generation Site-specific Antibody-drug Conjugates

Innate Pharma S.A. and Sanofi have entered into a collaboration agreement with Sanofi applies Innate Pharma's site-specific conjugation technology to the development of new...

Site-specific Conjugation Based on Bacterial Transglutaminase Shows Improved Therapeutic Index of...

The key conclusion of these posters is that ADCs generated by BTG-ADC have improved pharmacokinetics and show a beter therapeutic index in in vivo models compared to brentuximab, with a significantly higher maximum tolerated dose (>60mg/kg vs 18 mg/kg) and a higher specific tumoral uptake.