NCT02429375

Study Title
Mocetinostat (MGCD0103) Plus Brentuximab Vedotin (SGN-35) in Patients With Relapsed or Refractory Hodgkin Lymphoma (NCT02429375)

Trial Description
The purpose of this study is to find out how safe and effective treatment with a new combination of drugs, mocetinostat and brentuximab vedotin, is in treating cancer. There will be 2 parts to this trial: a phase I part and a phase II part.

Brentuximab vedotin (Adcetris®; Seattle Genetics/Millennium: The Takeda Oncology Company) is approved by the U.S. Food and Drug Administration (FDA) to be given to patients with Hodgkin Lymphoma. Mocetinostat, an orally-bioavailable, spectrum-selective HDAC inhibitor (HDACs 1, 2, 3 and 11), is an experimental drug being developed by Mirati Therapeutics (San Diego, CA), that has been given to patients with Hodgkin lymphoma in another clinical trial. When given alone, mocetinostat caused lymphoma to shrink in about 1 out of 4 patients with Hodgkin lymphoma. This is the first study that will give mocetinostat and brentuximab vedotin together.

This trial is sponsored by Memorial Sloan Kettering Hospital. [1]

Study Data

  • Condition: Hodgkin Lymphoma
  • Interventions:
  • Phase: I & II
  • Estimated Enrollment: 44
  • Start: April 2015
  • Estimated Primary Completion: April 2018
  • Last verified: April 2015

Study Schematic

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Last Editorial review: July 17, 2015
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.

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