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New ADC Payload Platform – Synaffix Launches toxSYN™

The Netherlands-based biotech company Synaffix, which has developed a proprietary site-specific conjugation platform technology to enable differentiated antibody-drug conjugates or ADCs, launched of a...

PEGG 2017: RESPECT Antibody-drug Conjugate Technology

Earlier this year, a record number of 2,300 delegates attended the 13th edition of the "PEGS: The Essential Protein Engineering Summit," held May 1...

Selenomab-drug Conjugates: Delivering Strong Results in Treating Cancers

Scientists from the Florida campus of The Scripps Research Institute (TSRI), one of the world's largest independent, not-for-profit organizations focusing on research in the...

Antibody-drug conjugates: Recent Advances in Conjugation and Linker Chemistries

Authors: Tsuchikama K , An Z Title: Antibody-drug conjugates: recent advances in conjugation and linker chemistries. Published in: Protein Cell. 2016 Oct 14. Keywords: antibody-drug conjugates; cancer;...

Site-specific Conjugation Based on Bacterial Transglutaminase Shows Improved Therapeutic Index of...

The key conclusion of these posters is that ADCs generated by BTG-ADC have improved pharmacokinetics and show a beter therapeutic index in in vivo models compared to brentuximab, with a significantly higher maximum tolerated dose (>60mg/kg vs 18 mg/kg) and a higher specific tumoral uptake.

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