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REGN3124-PBD a Novel EGFRvIII-selective ADC Shows Promise Against Glioblastoma Multiforme Patient-derived...

Glioblastoma Multiforme (GBM) is a highly aggressive primary malignant brain tumor with few specific molecular targets and poor therapeutic outcomes. The disease accounts for...

Preclinical Study Supports Continued Evaluation of CD25-targeted ADC in Selected Advanced...

Preclinical data for camidanlumab tesirine (formerly ADCT-301; ADC Therapeutics), published in the Journal for ImmunoTherapy of Cancer, the online journal of the Society for...

FDA Lifts Partial Clinical Hold on Pivotal Phase II Clinical Trial...

Earlier this week the U.S. Food and Drug Administration (FDA) lifted a partial clinical hold on the pivotal Phase II clinical study of camidanlumab...
Gesso Italiano (Italian Chalk) in San Diego's Little Italy neighborhood celebrating its heritage by bringing the vibrancy and flavors of Italy to southern California. Courtesy: 2016 Fotolia.

Advanced Design of ADCs: Principles and Applications using Next Generation Linkers...

Over the years there have been major challenges in the development of antibody-drug conjugates (ADC), including: choosing the right target, right antibody, right linker,...
Featured Image: View of Lugano old town with mountains in the background, Switzerland. Courtesy: © 2017. Fotolia. Used with permission.

Pyrrolobenzodiazepine-based ADCs Demonstrate Potential in R/R Lymphomas

The International Conference on Malignant Lymphoma (ICML) has, since its first edition in 1981, become one of the must-attend conferences for the scientific community...

What is Pyrrolobenzodiazepine (PBD)?

Pyrrolobenzodiazepine (PBD) Chemical Name: Diazepinoindole; Molecular Formula: C14H14N2O3 Molecular weight: 258,27 g/mole Average mass: 181.193 Da Monoisotopic mass: 181.063995 Da Introduction Discovered in 1963, the pyrrolobenzodiazepines (PBDs) are a class of antitumor antibiotics...

First Patient Dosed in Phase Ib Clinical Trial of Camidanlumab Tesirine...

A first patient has been dosed in Phase Ib clinical trial of camidanlumab tesirine, also know ADCT-301, a proprietary antibody-drug conjugate or ADC being...

Study Shows Concentration of Intratumoral Payload Correlates with ADC Activity

A study published in the March 2018 edition of Molecular Cancer Therapeutics shows that, while antibody–drug conjugates or ADC have become important scaffolds for...

Novel Cancer Therapeutics Drive Therapy Market

An increased need for better cancer treatment continues to boost the global cancer biological therapy market. According to a report published by Global Market...

Phase I Trial of SGN-CD352A in Relapsed or Refractory Multiple Myeloma...

This week the first patient enrolled in a multi-center phase I clinical trial of SGN-CD352A for the treatment of patients with relapsed or refractory...

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