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ADC Biotechnology Secures UK £1.14 million Investment

ADC Biotechnology has successfully secured UK £1.14 million in funding from, Downing LLP, a London-based investment management firm. The company, founded in 2010, is developing...

Downstream Processing Considerations for Antibody Variant Therapeutics

Abstract Novel platforms such as antibody derivatives, peptide based therapies, gene and stem cell based therapies are gaining foothold in the market for several reasons,...

Challenges and Strategies for the Downstream Processing of BiSpecific Antibodies (BsAbs)

Baeuerle and Raum present an extensive review of BsAbs in their article. [2] BsAbs are most commonly used for cancer immunotherapy where they are targeted to simultaneously bind to a cytotoxic cell as well as a target tumor cell to be destroyed. Targeting two antigens simultaneously can be a promising approach. This paper will include a review of the challenges associated with the manufacturing of BsAbs in mammalian cell cultures, and the strategies that can be implemented to overcome treatment challenges.