Data for several investigational compounds in the Daiichi Sankyo oncology pipeline will be presented at the upcoming annual meeting of the American Society of Clinical Oncology (ASCO) to be held May 31 to June 4, 2019 in Chicago, Illinois.
The highlights are expected to include the latest data for two investigational antibody-drug conjugates (ADCs) being evaluated in patients with non-small cell lung cancer (NSCLC), including first-in-human results for DS-1062, a TROP2 targeting ADC in advanced NSCLC, and the first phase II results for U3-1402, a HER3 targeting ADC, in EGFR mutated, TKI resistant metastatic NSCLC.
“We look forward to showcasing the broad applicability of our proprietary DXd ADC technology with initial results for DS-1062, our third ADC, which we designed to target TROP2 in lung and other cancers, and for U3-1402, which is being studied in lung and breast cancers,” said Antoine Yver, MD, MSc, EVP and Global Head, Oncology Research and Development, Daiichi Sankyo.
“The ASCO meeting presentations demonstrate the depth of our ADC pipeline beyond [fam-] trastuzumab deruxtecan (DS-8201), as well as the breadth of opportunities across our portfolio to translate our innovative science into potential new targeted cancer therapies.”
Both DS-1062 and U3-1402 are designed using Daiichi Sankyo’s proprietary DXd ADC technology, which consists of a humanized monoclonal antibody attached to a novel topoisomerase I inhibitor payload by a tetrapeptide-based linker. The ADCs were constructed to target and deliver chemotherapy inside cancer cells that express a specific cell surface antigen.
An overview of data from the Daiichi Sankyo oncology pipeline to be presented includes:
- First-in-human phase 1 study of DS-1062a in patients with advanced solid tumors (Abstract 9051. Poster Session: Lung Cancer – Non-Small Cell Metastatic. Sunday, June 2, 8:00 – 11:00 AM CDT)
- Safety and preliminary antitumor activity of U3-1402: A HER3-targeted antibody drug conjugate in EGFR TKI-resistant, EGFRm NSCLC (Abstract 9010. Clinical Science Symposium: EGFR and ROS1: Targeting Resistance. Lung Cancer – Non-Small Cell Metastatic. Friday, May 31, 1:00 – 2:30 PM CDT)
- A phase III, multicenter, randomized, open label trial of [fam-] trastuzumab deruxtecan (DS-8201a) versus investigator’s choice in HER2-low breast cancer (Abstract TPS1102. Poster Session: Breast Cancer – Metastatic. Sunday, June 2, 8:00 – 11:00 AM CDT)