The Review

What is Antibody Dependent Cell-Mediated Cytoxicity?

Antibody-Dependent Cell-mediated Cytotoxicity or ADCC is a critical mechanisms underlying the clinical efficacy of therapeutic anticancer antibodies; Granule...

What are Immunoglobulin G (IgG) Antibody Isotypes?

Each of the four immunoglobulin G or IgG antibody isotypes (IgG1,2,3 and 4), elicits different mechanisms of effector...

What are Monoclonal Antibodies?

Monoclonal antibodies (mAbs) or monospecific antibodies are a class of antibodies isolated in the laboratory from a single clone of a unique parent cells or...

Glossary

AAdventitious agentAn acquired, accidental, contaminant in a cell line.  This may include a virus or toxin.Adverse EventsAn unwanted or...
Featured Image: Ado-trastuzumab emtansine (Kadcyla; Genentech/Roche), known as T-DM1 during. Courtesy: Genentech/Roche.

How do ADCs work?

The antibody drug conjugate or ADC is a three-component system including a potent cytotoxic anticancer agent linked via a biodegradable linker...

What are Antibody-drug Conjugates?

Antibody-drug Conjugates or ADCs are highly targeted biopharmaceutical drugs that combine monoclonal antibodies specific to surface antigens present on...

Changing Strategies in the War on Cancer, Part 3

Over the last 25 years, there has been an explosion of new and vitally important, anticancer drugs.The development of...

Changing Strategies in the War on Cancer, Part 2

For decades, the hallmark of medical treatment for cancer and hematological malignancies has been intravenous cytotoxic chemotherapy. These drugs...

Changing Strategies in the War on Cancer, Part 1

The National Cancer Act signed in 1971 officially started what is commonly referred to as the “war against cancer.” Since...