The Review

What are the advantages of using monodisperse PEG in drug development?

Monodispersed PEG linkers are pure compounds with a single molecular weight. In contrast, polyPEG linkers contain variations in molecular...

What does a successful ADC look like?

A successful ADC is the one that works well in cancer patients with unmet medical needs where current approved...

What are the latest technologies being used to develop ADCs?

Targets Most targets of ADC have unique requirements, including  homogenous expression of ADC-accessible tumor surface antigens that internalize well and...

What is the clinical landscape for ADCs?

The clinical landscape of ADCs in both heme and solid cancers has grown to nearly 600 clinical trials incorporating...

What are the next generation ADCs?

In the last decade, there have unprecedented advances in discovery of new cytotoxic warheads of different mechanisms, new linkers...

What is Pyrrolobenzodiazepine (PBD)?

Structure of Pyrrolobenzodiazepine Pyrrolobenzodiazepine (PBD) Chemical Name: Diazepinoindole; Molecular Formula: C14H14N2O3 Molecular weight: 258,27 g/mole Average mass: 181.193 Da Monoisotopic mass: 181.063995 DaIntroduction Discovered in 1963, the pyrrolobenzodiazepines...

What is Monomethyl Auristatin F (MMAF)?

Monomethyl Auristatin F Chemical Name: (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acidMolecular Weight: 731.96 Formula: C39H65N5O8 CAS#: 141205-32-5 Solubility: DMSO up to 20 mMBiological Activity Monomethyl auristatin F (MMAF) or desmethyl-auristatin F is an...

What is Monomethyl Auristatin E (MMAE)?

Monomethyl Auristatin E Chemical Name: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide Molecular Weight: 717.98 Formula: C39H67N5O7 CAS: 474645-27-7 Solubility: DMSO up to 20 mMBiological Activity Monomethyl auristatin E (MMAE, vedotin) is a very potent antimitotic agent...

What is Maytansine?

Maytansine Chemical Name: L-alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclohexacosa-10,12,14(26),16,18-pentaen-6-yl ester,Molecular Weight: 692.19614 Formula: C34H46ClN3O10 CAS#: 35846-53-8Biological Activity Maytansine, a benzoansamacrolide, is a highly potent microtubule-targeted compound that induces...

What are Duocarmycin analogues?

Duocarmycin A Chemical Name: 1,2,4,5,8,8a-hexahydro-4-oxo-2--cyclopropapyrroloindole-6-carboxylic acid methyl ester, (+)-duocarmycin SA, duocarmycin SA, antibiotic DC 113 Molecular Weight: 477.47 Formula: C25H23N3O7 CAS#: 130288-24-3 Solubility: Sparingly Soluble (0.030 g/L) (25 ºC),...