What Are Drug-Linker Complexes?
Drug-linker complexes consist of two parts: a highly toxic drug which is a small molecule that interacts with intracellular targets and functions as agents...
What is Click Chemistry?
Click Chemistry has been used prominently in pharmaceutical and biotech R&D. It has become increasingly popular due its biocompatibility and its faster reaction speeds.1...
What does PEGylation Chemistry look like?
The introduction of a PEG linker to a molecule provides many benefits for pharmaceutical and biotech R&D due to its water solubility, lower toxicity...
What are the advantages of using monodisperse PEG in drug development?
Monodispersed PEG linkers are pure compounds with a single molecular weight. In contrast, polyPEG linkers contain variations in molecular weight with an average molecular...
What are PEG Peptides?
PEG Peptides are a featured class of PEG-linked peptides which can be used in antibody-drug conjugation (ADC).
What are PEG Linkers?
Hydrophilic poly(ethylene glycol) or PEG-linkers are particularly attractive as a linker for conjugation. Water solubility, lack of toxicity; low immunogenicity and well defined chain lengths...
What are Stable Linkers?
Summary
Linker Technologies
Type of linkers used in the development of Antibody-drug Conjugates (ADC)s
Stability of ADC in circulation
Prominent technologies Antibody–drug conjugates (ADCs) or immunoconjugates...
