Cytotoxic Agents and Antibody-drug Conjugates
Drug name
Target
Mode of Action
Example Auristatins
α-Tubulin
Prevent tubulin polymerization Monomethyl Auristatin E (MMAE)
Monomethyl Auristatin F (MMAF) Maytansinoids
α-Tubulin
Prevent tubulin polymerization Calicheamicins
Sequence-specific minor groove of...
What is Cryptophcin analog?
The cryptophycins are a group of cyanobacterial depsipeptides with a remarkable biological activity against multi-drug-resistant(MDR) cancer cells. As a potent...
What is Alpha-Amanitin?
Systematic name: (cyclic(L)-asparaginyl-4-hydroxy-L-proly-(R)-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl) cyclic (4 → 8)-sulfide(R)-S-oxide.
Molecular Formula: C39H54N10O14S
Molecular weight: 918.97 g/mol
Average mass: 918.970 Da
Monoisotopic mass: 918.354187 Da
CAS Registry: 23109-05-9
Solubility: Soluble in water (1.0 mg/ml), ethanol...
What are Cytotoxic Agents?
In this section:
Highly potent cytotoxic anticancer agents
Mechanism of Toxicity
Use in Antibody-drug Conjugates Auristatins
Tubulin polymerase inhibitor Maytansines
Tubulin depolymerisation Calicheamicins
DNA cleavage Duocarymycins
DNA...
