ADC Express: Rapid ADC Production from a Single Source
Earlier this year, during the 10th annual World ADC meeting held in San Diego, CA, MilliporeSigma, launched a new...
What is Pyrrolobenzodiazepine (PBD)?
Structure of Pyrrolobenzodiazepine Pyrrolobenzodiazepine (PBD) Chemical Name: Diazepinoindole; Molecular Formula: C14H14N2O3 Molecular weight: 258,27 g/mole Average mass: 181.193 Da Monoisotopic mass: 181.063995 Da Introduction Discovered in 1963, the pyrrolobenzodiazepines...
What is Monomethyl Auristatin F (MMAF)?
Monomethyl Auristatin F Chemical Name: (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid Molecular Weight: 731.96 Formula: C39H65N5O8 CAS#: 141205-32-5 Solubility: DMSO up to 20 mM Biological Activity Monomethyl auristatin F (MMAF) or desmethyl-auristatin F is an...
What is Monomethyl Auristatin E (MMAE)?
Monomethyl Auristatin E Chemical Name: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide Molecular Weight: 717.98 Formula: C39H67N5O7 CAS: 474645-27-7 Solubility: DMSO up to 20 mM Biological Activity Monomethyl auristatin E (MMAE, vedotin) is a very potent antimitotic agent...
What is Maytansine?
Maytansine Chemical Name: L-alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclohexacosa-10,12,14(26),16,18-pentaen-6-yl ester, Molecular Weight: 692.19614 Formula: C34H46ClN3O10 CAS#: 35846-53-8 Biological Activity Maytansine, a benzoansamacrolide, is a highly potent microtubule-targeted compound that induces...
What are Duocarmycin analogues?
Duocarmycin A Chemical Name: 1,2,4,5,8,8a-hexahydro-4-oxo-2--cyclopropapyrroloindole-6-carboxylic acid methyl ester, (+)-duocarmycin SA, duocarmycin SA, antibiotic DC 113 Molecular Weight: 477.47 Formula: C25H23N3O7 CAS#: 130288-24-3 Solubility: Sparingly Soluble (0.030 g/L) (25 ºC),...
What is Dolastatins (Dolastatin 10 and Dolastatin 15)?
Structure of Dolastatin 10 Dolastatin 10 Systematic name: N,N-Dimethyl-L-valyl-N-amino}propyl]-1-pyrrolidinyl}-5-methyl-1-oxo-4-heptanyl]-N-methyl-L -valinamide Molecular Formula: C42H68N6O6S Molecular weight 785.09092 g/mol Average mass: 785.091 Da Monoisotopic mass: 784.492126 Da Structure of Dolastatin 15 Dolastatin...
What is Centanamycin (ML-970; Indolecarboxamide)?
Chemical name: N--5,6,7-trimethoxy-1H-indole-2-carboxamide Centanamycin, also known as ML-970, AS-I-145 and NSC 716970, is an indolecarboxamide synthesized as a less toxic analog...
Calicheamicin and DNA-cleaving
Calicheamicins, isolated from Micromonospora echinospora ssp. calichensis, combine unprecedented and extraordinary chemical and biological properties. This includes activity in the biochemical...
What is Calicheamicin?
Calicheamicin (also known as LL-E33288 antibiotics) was first discovered in the mid-1980s by a scientist from American Cyanamid Company’s medical research division, Lederle...