Antibody-drug Conjugates

As innovative next-generation immunotherapeutic agents, antibody-drug conjugates (ADCs) are being developed worldwide as a major strategy to combat cancer and other immunological disorders. Customarily...

Antibody-drug conjugates (ADCs) are a new implementation of an old idea: using antibodies to deliver toxic payloads directly to tumor cells. The antibody serves...

Antibody-drug conjugates (ADCs) represent a rapidly growing class of anti-cancer therapeutics in which a potent small molecule is linked to a monoclonal antibody. To-date, two...

Over the last two decades researchers have been able to significantly advance the molecular sophistication and clinical efficacy of antibody-drug conjugates. Initial research was primarily...

What is biological therapy? Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat...

What Is Targeted Therapy? Targeted therapy is the foundation of precision medicine. It is a type of cancer treatment that targets the changes in cancer cells that...

A successful ADC is the one that works well in cancer patients with unmet medical needs where current approved therapies either work poorly or...

Targets Most targets of ADC have unique requirements, including  homogenous expression of ADC-accessible tumor surface antigens that internalize well and trafficked to lysosomes.  Ideally the...

The clinical landscape of ADCs in both heme and solid cancers has grown to nearly 600 clinical trials incorporating nearly 60 ADCs utilizing payload-warhead...

In the last decade, there have unprecedented advances in discovery of new cytotoxic warheads of different mechanisms, new linkers with highly stable DARs, warhead...