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Antibody-drug Conjugates

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Characterization of Antibody-drug Conjugates

Antibody-drug conjugates (ADCs) represent a rapidly growing class of anti-cancer therapeutics in which a potent small molecule is linked...

Targeting Cancer with Antibody-drug Conjugates

Over the last two decades researchers have been able to significantly advance the molecular sophistication and clinical efficacy of antibody-drug...

What Are Biological Therapies For Cancer?

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Featured Image: Cancer cell Courtesy: © 2018. Fotolia. Used with permission.

What are targeted therapies?

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What does a successful ADC look like?

A successful ADC is the one that works well in cancer patients with unmet medical needs where current approved...

What are the latest technologies being used to develop ADCs?

Targets Most targets of ADC have unique requirements, including  homogenous expression of ADC-accessible tumor surface antigens that internalize well and...

What is the clinical landscape for ADCs?

The clinical landscape of ADCs in both heme and solid cancers has grown to nearly 600 clinical trials incorporating...

What are the next generation ADCs?

In the last decade, there have unprecedented advances in discovery of new cytotoxic warheads of different mechanisms, new linkers...

Glossary

A Adventitious agent An acquired, accidental, contaminant in a cell line.  This may include a virus or toxin. Adverse Events An unwanted or...
Ado-trastuzumab emtansine (Kadcyla)

How do ADCs work?

The antibody drug conjugate or ADC is a three-component system including a potent cytotoxic anticancer agent linked via a biodegradable linker...

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