Home The Review

The Review

What does PEGylation Chemistry look like?

The introduction of a PEG linker to a molecule provides many benefits for pharmaceutical and biotech R&D due to...

What are the advantages of using monodisperse PEG in drug development?

Monodispersed PEG linkers are pure compounds with a single molecular weight. In contrast, polyPEG linkers contain variations in molecular...

What does a successful ADC look like?

A successful ADC is the one that works well in cancer patients with unmet medical needs where current approved...

What are the latest technologies being used to develop ADCs?

Targets Most targets of ADC have unique requirements, including  homogenous expression of ADC-accessible tumor surface antigens that internalize well and...

What is the clinical landscape for ADCs?

The clinical landscape of ADCs in both heme and solid cancers has grown to nearly 600 clinical trials incorporating...

What are the next generation ADCs?

In the last decade, there have unprecedented advances in discovery of new cytotoxic warheads of different mechanisms, new linkers...

What is Pyrrolobenzodiazepine (PBD)?

Structure of Pyrrolobenzodiazepine Pyrrolobenzodiazepine (PBD) Chemical Name: Diazepinoindole; Molecular Formula: C14H14N2O3 Molecular weight 258,27 g/mole Average mass: 181.193 Da Monoisotopic mass: 181.063995 Da Pyrrolobenzodiazepine (PBDs) are a class of sequence-selective...

What is Monomethyl Auristatin F (MMAF)?

Monomethyl Auristatin F Chemical Name: (S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid Molecular Weight: 731.96 Formula: C39H65N5O8 CAS#: 141205-32-5 Solubility: DMSO up to 20 mM Biological Activity Monomethyl auristatin F (MMAF) is an antitubulin agent agent that...

What is Monomethyl Auristatin E (MMAE)?

Monomethyl Auristatin E Chemical Name: (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide Molecular Weight: 717.98 Formula: C39H67N5O7 CAS: 474645-27-7 Solubility: DMSO up to 20 mM Biological Activity Monomethyl auristatin E (MMAE, vedotin) is a very potent antimitotic agent...

What is Maytansine?

Maytansine Chemical Name: L-alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclohexacosa-10,12,14(26),16,18-pentaen-6-yl ester, Molecular Weight: 692.19614 Formula: C34H46ClN3O10 CAS#: 35846-53-8 Biological Activity Maytansine, a benzoansamacrolide, is a highly potent microtubule-targeted compound that induces...

DOWNLOAD