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Sutro Biopharma and Celgene Expand Immuno-Oncology Product Discovery and Development Program

Sutro Biopharma, located in South San Francisco, and Celgene have entered into a strategic collaboration and option agreement designed...

Average DAR and DAR Distribution Assessment: The Analytical Potential of Native Mass Spectrometry and...

Antibody drug conjugates or ADCs are macromolecules which include cytotoxic drugs covalently attached via a conditionally stable linker to monoclonal antibodies...

Lilly and Zymeworks Expand Strategic Licensing and Collaboration – Broad Bi-Specific Antibody Development Now...

Originally announced in January 2014, a global strategic collaboration between Eli Lilly and Company and Zymeworks Inc. focused on...

Biotech Companies Agree To Co-Discover And Co-Develop Antibody-based Immunotherapies

PhosImmune Inc, based in Charlottesville, Virginia, USA . and PureMHC LLC, a platform technology company with expertise in disease-specific...

Study Shows Trastuzumab Emtansine is Well Tolerated by Japanese HER2-positive Metastatic Breast Cancer Patients

Ado-trastuzumab emtansine (Kadcyla®/T-DM1 Genentech/Roche), an antibody-drug conjugate composed of the cytotoxic agent DM1 conjugated to trastuzumab via a stable...

Efficacy of the Antibody-drug Conjugate PSMA-ADC in Patient-derived Prostate Cancer Xenografts

The prostate-specific membrane antigen (PSMA) is expressed in advanced prostate cancer and targeting this protein is used for imaging...

Combining Potent Antiandrogens and PSMA-targeted therapies in prostate-specific Membrane Antigen and Androgen Receptor in...

Clinical trials have shown that antibody-drug conjugates or ADCs are an emerging class of cancer therapies that have demonstrated...

Collagen-VI-Alpha-1 is a New Target and a Marker of Poor Outcome in Glioblastoma

Functional targeted therapy has unfortunately failed to improve the outcome of glioblastoma patients. While success stories evidenced by the...

Evaluating Therapeutic Efficacy of Antibodies (mAbs) or Antibody-drug Conjugates Targeting Receptor Tyrosine Kinases

Targeting Receptor Tyrosine Kinases or RTKs, widely expressed transmembrane proteins that act as receptors for growth factors, neurotrophic factors, and...

Vorinostat Downregulates the Expression of CD30 and Lowers the Efficacy of Brentuximab Vedotin

Over the last decade, the number of clinical trials looking at combination therapies has been been growing. As a...