Must Read Articles

Study Evaluates Pyrrolobenzodiazepine (PBD)-dimers Containing Disulfide-based Prodrugs as Payloads for Antibody-Drug Conjugates

A number of cytotoxic pyrrolobenzodiazepine (PBD) monomers containing various disulfide-based prodrugs were evaluated for their ability to undergo activation...
Scientist pipetting

Researchers Develop Novel anti-CD19 Antibody-drug Conjugates for the Treatment of B-cell Lymphoma

In an article published in July 2018 edition of the International Immunopharmacology researchers and scientists from RemeGen (Yantai 264006,...

Anti-CLL-1 ADC May Offer Effective and Safe Treatment Options for Patients with AML

Over the last 40 years treatment of acute myeloid leukemia or AML has not significantly changed.Today, the standard of...

Are Small-Format Drug Conjugates a Viable ADC Alternative Solid Tumors?

Antibody-drug conjugates or ADCs are complex immunoconjugates. They are designed to selectively deliver a small-molecules cytotoxic payload to cancer...

New Hydrophilic Auristatin Payload Improves Antibody-Drug Conjugate Efficacy and Biocompatibility

Antibody-drug conjugates or ADCs, which link an antibody to a potent, small-molecule, cytotoxic, cell-killing, chemotherapeutic agent, use the target-specificity...

Eric Rosenthal Reports: Why Academia Wasn’t Ready to Build Big Data Systems

Big news hit the pharmaceutical industry in February when Roche Pharmaceuticals announced that it would be acquiring big-data firm...

Study Shows Concentration of Intratumoral Payload Correlates with ADC Activity

A study published in the March 2018 edition of Molecular Cancer Therapeutics shows that, while antibody–drug conjugates or ADC...
Featured Image: American Society of Hematology | Annual Meeting. Courtesy: © 2017. American Society of Hematology. Used with permission.

Phase III ECHELON-1 Clinical Trial of Brentuximab Vedotin Meets Primary Endpoint – Demonstrates a...

Data from the Phase III ECHELON-1 clinical trial evaluating brentuximab vedotin (Adcetris®; Seattle Genetics | Takeda) as part of...

Market Trend: Cancer Immunotherapy Destined for Growth

According to data provided by Allied Market Research, the global cancer immunotherapy market is expected to grow to $117.14...

What Happens when the World of Pharma Returns to Frankfurt?

In October 2017 the 28th CPhI Worldwide returns to Frankfurt, Germany. This event takes place in a year where...