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New Data Demonstrates Potential for RemeGen’s RC48 in HER2+ Cancers

Results from a robust oncology pipeline, including the latest phase II data of an investigational antibody-drug conjugates (ADC) called...
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Sutro Presents Preliminary Results From Ongoing Phase I Study of STRO-001

California-based Sutro Biopharma has confirmed that the company will present preliminary results from the first 14 patients enrolled in...
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Site Specific Conjugation of Hydrophobic Payloads Without Genetic Engineering

Site-specific conjugation leads to more homogeneous conjugates and allows control of the site of drug attachment. This approach frequently...
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Understanding of the Underlying Mechanisms of Target-Independent Uptake and Toxicity

With 4 approved agents, antibody-drug conjugates or ADC have shown to be a very promising class of therapeutics.While the...

First-in-class Immunotherapeutic Approach Shows Efficacy in Neuroblastoma

Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia (CHOP) have developed a preclinical, potent therapy attached to...

Novel Payloads for Antibody-drug Conjugates

The development of antibody-drug conjugates or ADCs, has resulted in the need of developing novel compounds that can be...

Experts Forecasts CMOs to Benefit from Double Digit Approvals of ADCs

The global ADC therapeutics market is expected to grow to US $ 4bn by 2023, with double digit approvals...

How Meaningful Will Changes Be to Ethical Guidelines Following Jose Baselga’s Fall?

In the aftermath of the fall of renowned breast cancer researcher Jose Baselga, MD, PhD, following revelations last month...

Benefitting from the Worldwide Supply Chain in the development of Antibody-drug Conjugates

Timing is everything.Just over a decade ago, the pharmaceutical industry and R&D in China was dominated by generics and...

Four Ways to Show Nonobviousness of ADC Inventions

As research continues to progress and the scientific community’s appreciation for the power of ADCs has grown, so have the numbers. FDA has now approved at least four ADCs, and hundreds more are in development. The number of patent applications has also grown, with the U.S. Patent and Trademark Office (USPTO) publishing over two hundred patent applications with claims to ADC inventions in the last two years alone.