Prof. Julien Lescar, Ph.D is a biochemist and structural biologist with extensive experience in using X-ray crystallography and cryo-electron microscopy as a main tool for protein structure-function studies. He has determined the 3D structures of numerous viral proteins involved in RNA virus entry and virus replication for several major human pathogens (flaviviruses such as dengue virus or Zika virus, alphaviruses such as chikungunya virus, human metapneumovirus). In the last eight years, he has collaborated extensively with Professors Chuan Fa Liu and James Tam on identifying, characterizing and cloning several peptidyl asparaginyl ligases, with tremendous applications in biotechnology and biomedicine. His lab has conducted structural studies on recombinant asparaginyl ligases leading to a better understanding of their mechanism of action and accelerating their use for the rapid and precise bioconjugation of biomolecules such as nanobodies or full-length antibodies.
ADC Review, Journal of Antibody-drug Conjugates (ISSN 2327-0152) is an international peer-reviewed publication designed to serve the needs of a diverse community of individuals including academia, life sciences, pharma, research, clinicians and physicians. Along with regulatory affairs, we also cover government authorities and representatives from payers to policymakers.