Study Title
Study of RM-1929 and Photoimmunotherapy in Patients With Recurrent Head and Neck Cancer (NCT02422979)

Trial Description
This is a Phase I, two part, study of patients with recurrent Head and Neck Cancer (HNC), who in the opinion of their physician, cannot be satisfactorily treated with surgery, radiation or platinum chemotherapy.

Part I is a drug dose-escalation, fixed low fluency light application study to determine the drug dose that can be safely given to saturate the epidermal growth factor receptor (EGFR) at the tumor.

Part II is a light dose-escalation, fixed drug dosing infusion study to determine the optimal light application, in combination with the Part I drug dose, needed to achieve clinical response with an acceptable safety profile. Interim analysis will be performed after completion of Part I and prior to initiation of Part II. This trial is sponsored by Aspyrian Therapeutics. [1]

Study Data

  • Condition: Head and Neck Cancer
  • Interventions:
    • Drugs used in this trial
      • RM-1929
      • Device: Photoimmunotherapy
  • Phase: I
  • Estimated Enrollment: 24
  • Start: June 2015
  • Estimated Completion: September 2016
  • Last verified: June 2015

Study Schematic 

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Last Editorial review: July 8, 2015
Information based on (NIH/NCI) and other sources.

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