Phase I/II Study of Bosutinib in Combination With Inotuzumab Ozogamicin in CD22-positive Philadelphia-Chromosome (PC) Positive Acute Lymphoblastic Leukemia (ALL) and Chronic Myeloid Leukemia (CML) (NCT02311998)
There are 2 parts to this study: Part 1 (dose escalation) and Part 2 (dose expansion).
The goal of Part 1 of this clinical research study is to find the highest tolerable dose of the combination of bosutinib and inotuzumab ozogamicin (also known as CMC-544) that can be given to patients with Ph+ ALL and CML in the lymphoid blast phase that also expresses CD22.
The goal of Part 2 is to learn if the dose found in Part 1 can help to control the disease.
The safety of this drug combination will also be studied.
- Condition: Leukemia
- Phase: I & II
- Estimated Enrollment: 40
- Start: April 2015
- Estimated Primary Completion: April 2020
- Last verified: June 2015
Last Editorial review: July 31, 2016
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.
Copyright © 2015-2016 InPress Media Group. All rights reserved. Republication or redistribution of InPress Media Group content, including by framing or similar means, is expressly prohibited without the prior written consent of InPress Media Group. InPress Media Group shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. ADC Review / Journal of Antibody-drug Conjugates is a registered trademarks and trademarks of InPress Media Group around the world.