Study Title
Brentuximab Vedotin Followed by ABVD in Patients With Previously Untreated Hodgkin Lymphoma (NCT02275598)

Trial Description
The purpose of this study is to assess the efficacy of two three-weekly 1.8 mg/kg brentuximab vedotin administrations in untreated patients with Hodgkin Lymphoma (HL).

In this trial, treatment with the antibody-drug conjugate brentuximab vedotin is followed with the standard ABVD regimen, a combination of 4 chemotherapy drugs (doxorubicin, bleomycin, vinblastine, and dacarbazine) which was developed in the early 1970’s as an alternative to MOPP (mechlorethamine, vincristine, procarbazine and prednisone).  The MOPP regimen was first combination regimen for the treatment of Hodgkin’s disease developed in 1964 by researchers at the National Cancer Institute.

This trial is sponsored by University of Modena and Reggio EmiliaMillennium Pharmaceuticals. [1]

Study Data

Study Schematic

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Last Editorial review: July 18, 2016
Information based on (NIH/NCI) and other sources.

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