Study Title
Everolimus and Brentuximab Vedotin in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma (NCT02254239)
Trial Description
This phase I trial studies the side effects and the best dose of everolimus when given together with brentuximab vedotin in treating patients with Hodgkin lymphoma that has come back (relapsed) or is not responding to treatment (refractory). Everolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Brentuximab vedotin (also known as SGN-035) may interfere with the ability of cancer cells to grow and spread by binding to a protein on the surface of cancer cells and then releasing a cancer-killing substance to them. Giving everolimus together with brentuximab vedotin may be a better treatment for Hodgkin lymphoma.
This trial is sponsored by Mayo Clinic/ National Cancer Institute (NCI) [1]
Study Data
- Condition: Lymphoma
- Interventions:
- Drugs used in this trial
- everolimus (Afinitor® / Zortress®; Novartis Pharmacueticals Co.)
- brentuximab vedotin (Adcetris®; Seattle Genetics, Inc.)
- pharmacological study
- laboratory biomarker analysis
- Drugs used in this trial
- Phase: I
- Estimated Enrollment: 26
- Start: September 2015
- Estimated Primary Completion: September 2020 (Final data collection date for primary outcome measure)
- Last verified: June 2015
Study Schematic
Last Editorial review: July 11, 2016
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.
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