Ado-Trastuzumab Emtansine(T-DM1) + ABT-737 in Treating Patients With HER2(+) Breast Cancer (NCT02070094)
The purpose of this study was whether the combination of two different drugs – is safe Trastuzumab Emtansine (T-DM1) (Kadcyla®; Genentech, Inc.) and ABT- 737 , and if it can be effective in treating breast cancer.
This trial is sponsored by Ukrainian Anti Cancer Institute. 
- Condition: Breast Cancer
- Phase: I & II
- Enrollment: 0
- Start: October 2013
- Estimated Completion: September 2015
- Last verified: February 2014
* ABT 737 is a novel and highly potent small molecule inhibitor of Bcl-2, a central regulator of cell survival that is overexpressed in the majority of small cell lung cancers (SCLC) and contributes to both malignant transformation and therapeutic resistance. Bcl-2 overexpression is also associated with an increased risk of local recurrence in patients with early stage breast cancer. 
A number of trials have shown that by targeting the anti-apoptotic proteins Bcl-2 and Bcl-xL with ABT-737 in breast cancer the acquired radioresistance of MDA-MB-231R cells in vitro and in vivo may be reversed. These findings suggest an attractive strategy for overcoming the acquired radioresistance of breast cancer cells. 
Last Editorial review: July 27, 2015
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.
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