NCT01995188 (Clinical Trial/ Lifastuzumab vedotin / anti-NaPi2b ADC / RG-7599 / DNIB0600A)

Study Title
A Study to Evaluate the Safety and Pharmacology of DNIB0600A in Patients With Ovarian Cancer (NCT01995188)

Trial Description
This open-label, multicenter, phase Ib study will evaluate the safety and pharmacokinetics of DNIB0600A ( also known as lifastuzumab vedotin / anti-NaPi2b ADC / RG-7599 / DNIB0600A) in patients with platinum-sensitive ovarian cancer. The maximum tolerated dose of intravenously infused DNIB0600A in combination with carboplatin will be determined in escalating dose cohorts. The combination of DNIB0600A and carboplatin will then be evaluated with and without bevacizumab [Avastin] in two dose expansion cohorts.

This trial is sponsored by Genentech. [1]

Study Data

  • Condition:
  • Interventions:
    • Drugs used in this trial
      • DNIB0600A (Lifastuzumab vedotin; anti-NaPi2b ADC; RG-7599; DNIB0600A)
      • bevacizumab (Avastin®;Genentech, Inc.)
      • carboplatin
  • Phase: I
  • Estimated Enrollment: 42
  • Start: December 2013
  • Estimated Completion: September 2016
  • Last verified: July 2015

Study Schematic 

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Last Editorial review: July 10, 2015
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.

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