NCT01915472 (Clinical Trial/ Labetuzumab-SN-38 / IMMU-130 / hMN-14-SN38)

Study Title
A Phase II Study of IMMU 130 in Patients With Metastatic Colorectal Cancer (NCT01915472)

Trial Description
This is a Phase II trial to study the safety and efficacy of IMMU-130 (also known as labetuzumab-SN-38 or hMN-14-SN38). IMMU-130 is composed of a drug attached to an antibody. The drug is the active ingredient in irinotecan which is a common chemotherapy drug used for colorectal cancer. Antibodies are proteins normally made by the immune system. They bind to substances that don’t belong in the body to prevent harm to the body.

The antibody in this study was designed to bind to a marker located on colorectal cancer tumors. The antibody was originally made from mouse proteins, but was changed in the laboratory to be more like human antibodies. This study will investigate how IMMU-130 acts for the treatment of colorectal cancer. The study is mainly being done to see if IMMU-130 is safe and effective.

This trial is sponsored by Immunomedics. [1]

Study Data

  • Condition: Colorectal Cancer
  • Interventions:
    • Drugs used in this trial
      • IMMU-130 (Labetuzumab-SN-38; IMMU-130; hMN-14-SN38)
  • Phase: II
  • Estimated Enrollment: 50
  • Start: September 2013
  • Estimated Primary Completion: August 2015
  • Last verified: August 2013

Study Schematic 

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Last Editorial review: July 10, 2015
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.

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