NCT01309789 (CLINICAL TRIAL / BRENTUXIMAB VEDOTIN / SGN-035 / ADCETRIS®)

Study Title
A Phase 1 Study of Brentuximab Vedotin Given Sequentially and Combined With Multi-Agent Chemotherapy for CD30-Positive Mature T-Cell and NK-Cell Neoplasms (NCT01309789)

Trial Description
The purpose of this study is to assess the safety profile of brentuximab vedotin sequentially and in combination with multi-agent chemotherapy in front-line treatment for CD30-positive mature T-cell and NK-cell neoplasms, including systemic anaplastic large cell lymphoma. It is a phase I, open-label, dose escalation study in three arms designed to define the MTD, PK, immunogenicity, and anti-tumor activity of the antibody-drug conjugate brentuximab vedotin in sequence and in combination with multi-agent front-line chemotherapy.

This trial is sponsored by Millennium Pharmaceuticals/Seattle Genetics. [1]

Study Data

Study Schematic

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Last Editorial review: July 15, 2016
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.

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