NCT00928330 (Clinical Trial/ Ado-Trastuzumab Emtansine)

Study Title
Trastuzumab and Trastuzumab-MCC-DM1 Administered Intravenously and GDC-0941 Administered Orally to Patients With HER2-Positive Metastatic Breast Cancer Who Have Progressed on Previous Trastuzumab-Based Therapy (NCT00928330)

Trial Description
This multicenter, Phase Ib study is an open label, dose escalation, three-arm study evaluating the safety, tolerability, pharmacokinetics, and activity of oral (PO) GDC 0941 administered in combination with either intravenous (IV) infusion of ado-trastuzumab emtansine (T-DM1, Kadcyla®; Genentech, Inc.) or IV infusion of trastuzumab (Herceptin®;Genentech, Inc.).

This trial is sponsored by Genentech, Inc. [1]

Study Data

  • Condition: Metastatic Breast Cancer
  • Interventions:
  • Phase: I
  • Enrollment: 57
  • Start: July 2009
  • Completion: January 2014
  • Last verified: July 2015

Study Schematic

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Last Editorial review: July 29, 2015
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.

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