NCT00673153 (Clinical Trial / Gemtuzumab Ozogamicin)

Study Title
Vorinostat and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia (NCT00673153)

Trial Description
Vorinostat (Zolinza®; Merck & Co.) may stop the growth of cancer cells by interfering with various proteins needed for cell growth. Monoclonal antibodies, such as the antibody-drug conjugate gemtuzumab ozogamicin (Mylotarg®; Pfizer/Wyeth-Ayerst Laboratories), can block cancer growth in different ways. GO finds cancer cells and helps kill them by carrying a cancer-killing substance to them. Giving vorinostat together with gemtuzumab ozogamicin may kill more cancer cells.

This phase II trial is studying how well giving vorinostat together with gemtuzumab ozogamicin works in treating older patients with previously untreated acute myeloid leukemia.

This trial is sponsored by Fred Hutchinson Cancer Research Center. [1]

Study Data

  • Condition:
    • Adult Acute Megakaryoblastic Leukemia (M7)
    • Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
    • Adult Acute Monoblastic Leukemia (M5a)
    • Adult Acute Monocytic Leukemia (M5b)
    • Adult Acute Myeloblastic Leukemia With Maturation (M2)
    • Adult Acute Myeloblastic Leukemia Without Maturation (M1)
    • Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
    • Adult Acute Myeloid Leukemia With Del(5q)
    • Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
    • Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
    • Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
    • Adult Acute Myelomonocytic Leukemia (M4)
    • Adult Erythroleukemia (M6a)
    • Adult Pure Erythroid Leukemia (M6b)
    • Untreated Adult Acute Myeloid Leukemia
  • Interventions:
  • Phase: II
  • Estimated Enrollment: 107
  • Start: March 2008
  • Primary Completion: August 2010
  • Last verified: November 2011

Study Schematic

(Coming soon)

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Last Editorial review: July 20, 2015
Information based on (NIH/NCI) and other sources.

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