NCT00577694 (Clinical Trial / Gemtuzumab Ozogamicin)

Study Title
Clofarabine and Gemtuzumab in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (NCT00577694)

Trial Description
Drugs used in chemotherapy, such as clofarabine (Clolar®; Sanofi-Aventis U.S. LLC), work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.

Monoclonal antibodies, including antibody-drug conjugates or ADCs such as gemtuzumab ozogamicin (Mylotarg®; Pfizer/Wyeth-Ayerst Laboratories), can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving clofarabine together with gemtuzumab may kill more cancer cells.

This phase I trial is studying the side effects and best dose of clofarabine when given together with gemtuzumab in treating patients with relapsed or refractory acute myeloid leukemia.

This trial is sponsored by UNC Lineberger Comprehensive Cancer Center. [1]

Study Data

Study Schematic

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Last Editorial review: July 22, 2015
Information based on (NIH/NCI) and other sources.

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