A Trial of Gemtuzumab Ozogamicin (GO) in Combination With Zosuquidar in Patients With CD33 Positive Acute Myeloid Leukemia (NCT00233909)
Chemotherapy drugs use different ways to stop cancer cells from dividing so they stop growing or die. The P-glycoprotein inhibitors Zosuquidar (also known as LY 335979; RS 33295; RS 33295-198; Zosuquidar trihydrochloride) may help gemtuzumab ozogamicin (Mylotarg®; Pfizer/Wyeth-Ayerst Laboratories) kill more cancer cells by making cancer cells more sensitive to the drug. It is not known whether Gemtuzumab Ozogamicin (GO) is more effective with or without zosuquidar in treating acute myeloid leukemia (AML).
This trial is sponsored by Kanisa Pharmaceuticals, Inc. 
- Condition: Myeloid Leukemia
- Phase: I & II
- Estimated Enrollment: 55
- Start: October 2005
- Completion: March 2008
- Last verified: March 2008
* The investigational drug zosuquidar trihydrochloride (a difluorocyclopropyl quinoline), which modulates P-glycoprotein (P-gp) with minimal delay of anthracycline clearance, may reverse P-gp-mediated multi-drug resistance (MDR) in acute myeloid leukemia (AML) without increased toxicity. P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents.
Last Editorial review: July 21, 2015
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.
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