NCT00028899 (Clinical Trial / Gemtuzumab Ozogamicin)

Study Title

Monoclonal Antibody Plus Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes (NCT00028899)

Trial Description

Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies, such as the antibody-drug conjugates or ADCs gemtuzumab ozogamicin (Mylotarg®; Pfizer/Wyeth-Ayerst Laboratories), can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Combining monoclonal antibody therapy with combination chemotherapy may kill more cancer cells.

Phase I trial to study the effectiveness of combining gemtuzumab ozogamicin with combination chemotherapy in treating children who have relapsed or refractory acute myeloid leukemia or myelodysplastic syndrome.

This trial is sponsored by Children’s Oncology GroupNational Cancer Institute (NCI). [1]

Study Data

Study Schematic

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Last Editorial review: July 23, 2015

Information based on (NIH/NCI) and other sources.

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