Oblimersen and Gemtuzumab Ozogamicin in Treating Older Patients With Relapsed Acute Myeloid Leukemia (NCT00017589)
Monoclonal antibodies, including antibody-drug conjugates such as gemtuzumab ozogamicin, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Oblimersen may help gemtuzumab ozogamicin kill more cancer cells by making cancer cells more sensitive to the drug.
Phase II trial to study the effectiveness of combining oblimersen and gemtuzumab ozogamicin in treating older patients who have relapsed acute myeloid leukemia.
This trial is sponsored by Genta Inc.*/ National Cancer Institute (NCI). 
- Condition: Leukemia
- Phase: II
- Start: December 2000
- Completion: May 2006
- Last verified: April 2003
* In August 2012 Genta Inc. filed for bankruptcy.
**Genasense® (oblimersen sodium) is a compound that blocks production of the Bcl-2 protein. By first lowering levels of Bcl-2, it is possible that chemotherapy drugs may work more effectively as a cancer treatment. Genasense® may also directly kill CLL cells.
Last Editorial review: July 22, 2015
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.
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